protein kinase, required for the assembly of several outer coat proteins
function
protection of CotU and CotC in the mother cell
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|GerE regulon], [SW|SigK regulon], [SW|SigE regulon], [SW|SpoIIID regulon]Gene
Coordinates on the chromosome (coding sequence)
3,716,009 -> 3,717,097
Phenotypes of a mutant
overexpression of ''cotH'' suppresses the phenotypes of a ''[protein|search|cotE]'' mutant [Pubmed|24086406]reduced [SW|germination] efficiency [Pubmed|27185916]The protein
Catalyzed reaction/ biological activity
autophosphorylation with ATP and subsequent phosphorylation of [SW|CotB] and [SW|CotG] on serine residues [Pubmed|27185916]Protein family
cotH family (according to Swiss-Prot)[SW|Cofactors]
Structure
[PDB|5JD9] [Pubmed|27185916][SW|Localization]
inner spore coat[SW|Interactions]
[protein|search|CotE]-[protein|search|CotH] [Pubmed|26484546][protein|search|CotB]-[protein|search|CotH] [Pubmed|27185916][protein|search|CotG]-[protein|search|CotH] [Pubmed|27185916]Expression and Regulation
Operon
''[protein|search|cotH]-[protein|search|cotB]-[protein|search|ywrJ]'' [Pubmed|22383849][SW|Sigma factor]
[SW|SigE], [protein|search|SigK] [Pubmed|15699190,8755863]Regulation
expressed late during sporulation in the mother cell ([SW|SigE], [protein|search|SigK], [protein|search|GerE], [SW|SpoIIID]) [Pubmed|26577401,15699190,8755863,15470121]Regulatory mechanism
[protein|search|GerE]: transcription repression [Pubmed|15470121][protein|search|SpoIIID]: transcription activation [Pubmed|26577401]References
10198031,15699190,8755863,15470121,18065538,24086406,21984783,25259857,25115591,26484546,26953338,27185916,14762006,26577401 
