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murG
UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, conversion of lipid I to lipid II
Molecular weight
39.82 kDa
Function
peptidoglycan precursor biosynthesis
Product
UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Genomic Context
Categories containing this gene/protein
Gene
Coordinates
1,591,540 → 1,592,631
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
converts lipid I to lipid II by attaching GlcNAc to the bactoprenol carrier-conjugated UDP-N-acetylmuramic acid (UDP-MurNAc) pentapeptide moleculeMur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-α-D-glucosamine --> β-D-GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H+ + UDP (according to UniProt)Protein family
glycosyltransferase 28 family (with UgtP and YkoN, according to UniProt) Structure
1F0K (from Escherichia coli, 30% identity, 52% similarity) PubMed Localization
peripheral membrane protein PubMedin the presence of daptomycin, MurG delocalizes from the membrane to the cytoplasm PubMedforms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed Expression and Regulation
Operons
Sigma factors
Regulatory mechanism
Regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell (SigE) PubMed view in new tabRegulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell (SigE) PubMed view in new tabBiological materials
References
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