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qcrA [Mon Aug 31 2015 13:55:17 GMT+0200 (CEST)]
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qcrA [Mon Aug 31 2015 13:55:17 GMT+0200 (CEST)]

Rieske factor, menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit), component of the cytochrome bc1 complex
locus
BSU22560
pI
6.08
mw
18.00 kDa
function
respiration
product
menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)
essential
no
synonyms
bfcA, petC

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.4|Respiration/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • syns
    bfcA, petC

    [SW|Categories] containing this gene/protein

  • [SW|respiration], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|CcpA regulon], [SW|ResD regulon]
  • The protein

    Protein family

  • accD/PCCB family (according to Swiss-Prot)
  • [SW|Cofactors]

  • contains an iron-sulfur cluster
  • [SW|Localization]

  • cell membrane [Pubmed|23880299]
  • delivered to the membrane by the [SW|TatAY]-[SW|TatCY] [SW|protein secretion] system, this depends on prior dusulfide bond formation and co-factor insertion [Pubmed|24652282,23256564]
  • [SW|Interactions]

  • part of a [SW|respiratory supercomplex] [Pubmed|23880299]
  • [protein|search|QcrA]-[protein|search|QcrB]-[protein|search|QcrC] [Pubmed|23880299]
  • Expression and Regulation

    Operon

  • ''[protein|search|qcrA]-[protein|search|qcrB]-[protein|search|qcrC]'' [Pubmed|7592464]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|7592464]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by oxygen limitation ([protein|search|ResD]) [Pubmed|8631715]
  • repressed by glucose (5.5-fold) ([protein|search|CcpA]) [Pubmed|12850135]
  • Regulatory mechanism

  • [protein|search|ResD]: transcription activation [Pubmed|8631715]
  • [protein|search|CcpA]: transcription repression [Pubmed|12850135]
  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]
  • References

    Reviews

  • 24140208
  • Original publications

  • 8631715,7592464,23880299,12850135,12107147,20817675,23256564,24652282,26239117