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gtaB [Mon Oct 10 2016 15:28:13 GMT+0200 (CEST)]
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gtaB [Mon Oct 10 2016 15:28:13 GMT+0200 (CEST)]

UTP-glucose-1-phosphate uridylyltransferase, general stress protein
Locus
BSU35670
Isoelectric point
4.00
Molecular weight
32.00 kDa
Function
biosynthesis of teichoic acid
Product
UTP-glucose-1-phosphate uridylyltransferase
Essential
no
E.C.
2.7.7.9
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
  • Metabolism → Lipid metabolism → Lipid metabolism/ other
  • Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
  • Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
  • Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue
  • Groups of genes → Phosphoproteins → Phosphorylation on either a Ser, Thr or Tyr residue

    • Categories containing this gene/protein

  • cell wall synthesis, lipid metabolism/ other, biosynthesis of cell wall components, general stress proteins (controlled by SigB), phosphoproteins, sporulation/ other

    • This gene is a member of the following regulons

  • SigB regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,665,629 -> 3,666,507

    Phenotypes of a mutant

  • the inactivation of gtaB suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed
  • inactivation of gtaB reduces sporulation efficiency to 0.1% that of wild type cells; smaller, wider mother cells with small forespores PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • UTP alpha-D-glucose 1-phosphate = diphosphate UDP-glucose (according to Swiss-Prot)

    • Protein family

  • UDPGP type 2 family (according to Swiss-Prot)

    • Paralogous protein(s)

  • YngB, YtdA

    • Modification

  • phosphorylated on Arg-76 PubMed
  • phosphorylated on ser/ thr/ tyr PubMed

    • Structure

  • 2E3D (from E. coli, 44% identity, 61% similarity) PubMed

    • Expression and Regulation

    Operon

  • gtaB PubMed

    • Sigma factor

  • SigA PubMed, SigB PubMed

    • Regulation

  • induced by stress (SigB) PubMed

    • References

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