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nadB [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]
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nadB [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]

L-aspartate oxidase
locus
BSU27870
pI
6.45
mw
58.00 kDa
function
NAD biosynthesis
product
L-aspartate oxidase
essential
no
ec
1.4.3.16
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|NadR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • L-aspartate + O2 = iminosuccinate + H2O2 (according to Swiss-Prot)

    • Protein family

  • NadB subfamily (according to Swiss-Prot)

    • Modification

  • phosphorylated on Arg-104 [Pubmed|22517742]

    • Expression and Regulation

    Operon

  • ''[protein|search|nadB]-[protein|search|nadC]-[protein|search|nadA]'' [Pubmed|8444804]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8444804]

    • Regulation

  • repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]

    • Regulatory mechanism

  • [protein|search|NadR]: transcription repression [Pubmed|16199587]

    • Labs working on this gene/protein

  • [SW|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]

    • References

  • 8444804,18959769,16199587,20525796,22517742