folK [Wed Feb 15 2017 18:06:36 GMT+0100 (CET)]

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

locus: BSU00790

pI: 4.00

mw: 18.00 kDa

function: biosynthesis of folate

product: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

essential: yes

ec: 2.7.6.3

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 86,946 -> 87,449

Phenotypes of a mutant

• essential [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• ATP 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (according to Swiss-Prot)

Protein family

• HPPK family (according to Swiss-Prot)

Structure

• [PDB|1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) [Pubmed|12578370]

Expression and Regulation

Operon

• ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9084182]

References

Reviews

• 28031352

Original publications

• 9084182,28189581