lexA [Mon Aug 31 2015 13:54:34 GMT+0200 (CEST)]

transcriptional repressor of the SOS regulon

Locus: BSU17850

Isoelectric point: 5.16

Molecular weight: 22.00 kDa

Function: regulation of DNA damage repair

Product: transcriptional repressor of the SOS regulon

Essential: no

Synonyms: dinR

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA repair/ recombination
• Information processing → Genetics → DNA repair/ recombination → Other proteins
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Syns: dinR

Categories containing this gene/protein

• DNA repair/ recombination, transcription factors and their control

This gene is a member of the following regulons

• LexA regulon

The protein

Catalyzed reaction/ biological activity

• Represses uvrB, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (according to Swiss-Prot)

Protein family

• peptidase S24 family (according to Swiss-Prot)

Structure

• 1JHH (from E. coli, S119A mutant, 33% identity, 52% similarity) PubMed

Expression and Regulation

Operon

• lexA PubMed

Regulation

• induced upon DNA damage (LexA) PubMed

Regulatory mechanism

• autorepression
• LexA: transcription repression PubMed

References

Reviews

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Original publications

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