transcriptional repressor of the SOS regulon
function
regulation of DNA damage repair
product
transcriptional repressor of the SOS regulon
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|LexA regulon]The protein
Catalyzed reaction/ biological activity
Represses ''[protein|search|uvrB], [protein|search|dinB], [protein|search|dinC], [protein|search|recA]'' genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, [protein|search|RecA] interacts with [protein|search|LexA] causing an autocatalytic cleavage which disrupts the DNA-binding part of [protein|search|LexA], leading to derepression of the SOS regulon and eventually DNA repair. (according to Swiss-Prot)Protein family
peptidase S24 family (according to Swiss-Prot)Structure
[PDB|1JHH] (from ''E. coli'', S119A mutant, 33% identity, 52% similarity) [Pubmed|11551506]Expression and Regulation
Operon
''[protein|search|lexA]'' [Pubmed|1657879]Regulation
induced upon DNA damage ([protein|search|LexA]) [Pubmed|1657879,8899710,16267290]Regulatory mechanism
autorepression[protein|search|LexA]: transcription repression [Pubmed|1657879,8899710,16267290]References
Reviews
Original publications
8899710,9045831,9555905,8969214,1657879,16267290,11551506,16549676,20525796 
