hemC [Tue Feb 09 2016 20:33:43 GMT+0100 (CET)]

hydroxymethylbilane synthase

locus: BSU28150

pI: 5.00

mw: 34.00 kDa

function: heme biosynthesis

product: hydroxymethylbilane synthase

essential: no

ec: 2.5.1.61

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|PerR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,875,951 -> 2,876,895

The protein

Catalyzed reaction/ biological activity

• 4 porphobilinogen H₂O = hydroxymethylbilane 4 NH₃ (according to Swiss-Prot)

Protein family

• HMBS family (according to Swiss-Prot)

Structure

• [PDB|4MLQ] (from ''Bacillus megaterium'', 70% identity)

Expression and Regulation

Operon

• ''[protein|search|hemA]-[protein|search|hemX]-[protein|search|hemC]-[protein|search|hemD]-[protein|search|hemB]-[protein|search|hemL]'' [Pubmed|1672867]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1672867]

Regulation

• induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

Regulatory mechanism

• [protein|search|PerR]: transcription repression [Pubmed|11532148]

References

• 10217486,1672867,11532148