hemC [2017-8-11 16:0:3]

hydroxymethylbilane synthase

locus: BSU28150

pI: 5.09

mw: 34.68 kDa

protein length: 314 aa

gene length: 942 bp

function: heme biosynthesis

product: hydroxymethylbilane synthase

essential: no

ec: 2.5.1.61

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

Gene

Coordinates: 2,875,951 → 2,876,895

The protein

Catalyzed reaction/ biological activity

• 4 porphobilinogen + H₂O = hydroxymethylbilane + 4 NH₃ (according to Swiss-Prot)

Protein family

• HMBS family (according to Swiss-Prot)

Structure

• [PDB|4MLQ] (from ''Bacillus megaterium'', 70% identity) [Pubmed|24598743]

Expression and Regulation

Operons

• count: 2
  genes: [gene|B1413EB525000744BE8E429E760220A13BC4530D|hemA]-[gene|88616BA1E853E11BE0CB18F06287CA4C68143148|hemX]-[gene|D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B|hemC]-[gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]-[gene|70263A55987F110209367CF45AD65A584AD3077D|hemB]-[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]
  description: [Pubmed|1672867]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1672867], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR]: repression, [Pubmed|11532148], in [regulon|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR regulon]

  regulation

  • induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

References

Reviews

• 28123057

Original Publications

• 10217486,1672867,11532148,24598743