RNA polymerase ECF-type sigma factor SigV, required for resistance to lytic enzymes
function
resistance to lytic enzymes
product
RNA polymerase ECF-type sigma factor SigV
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][SW|Categories] containing this gene/protein
[SW|transcription], [SW|sigma factors and their control], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]This gene is a member of the following [SW|regulons]
[SW|SigV regulon]Gene
Coordinates on the chromosome (coding sequence)
2,769,850 -> 2,770,350
Phenotypes of a mutant
increased sensitivity to lysozyme, this can be suppressed by overexpression of'' [protein|search|oatA]'' [Pubmed|21856855]The protein
Protein family
ECF subfamily (according to Swiss-Prot)Effectors of protein activity
activity is controlled by the interaction with [protein|search|RsiV], proteolytic degradation of [protein|search|RsiV] releases active [protein|search|SigV] [Pubmed|23687273][SW|Interactions]
[protein|search|SigV]-[protein|search|RsiV], this interaction inhibits the activity of [protein|search|SigV] [Pubmed|23687273][protein|search|SigV]-([protein|search|RpoB]-[protein|search|RpoC])Additional information
Expression of the [SW|SigV regulon] in increased in ''[protein|search|ugtP]'' mutants [Pubmed|22362028]Expression and Regulation
Operon
''[protein|search|sigV]-[protein|search|rsiV]-[protein|search|oatA]-[protein|search|yrhK]'' [Pubmed|21856855][SW|Sigma factor]
[protein|search|SigV] [Pubmed|21856855]Regulation
induced by lysozyme ([protein|search|SigV]) [Pubmed|21856855]Biological materials
Mutant
1A907 ( ''sigV''::''kan''), [Pubmed|15838020], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A907&Search=1A907 BGSC]Labs working on this gene/protein
[SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas Wiegert-Dateien/Thomas Wiegert.html Homepage]References
Reviews
Original publications
14993308,16274938,17675383,19745567,22362028,23687273,20817771,21926231,21856855,26399770 
