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kduI
5-keto-4-deoxyuronate isomerase
function
utilization of galacturonic acid
product
5-keto-4-deoxyuronate isomerase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]Gene
Coordinates
2,325,854 → 2,326,681
The protein
Catalyzed reaction/ biological activity
5-dehydro-4-deoxy-D-glucuronate --> 3-deoxy-D-glycero-2,5-hexodiulosonate (according to UniProt)Protein family
KduI family (single member, according to UniProt)Structure
[PDB|1YWK] (from Enterococcus faecalis, 48% identity)Expression and Regulation
Operons
genes
[gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]-[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]
description
[Pubmed|17322190]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17322190], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[protein|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR]: repression, [Pubmed|17322190], in [regulon|891A32A19D1353BA566FF121BBCA7B986D31D129|KdgR regulon][protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|17322190], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]regulation
induced by galacturonate ([protein|search|KdgR]) [Pubmed|17322190]view in new tabBiological materials
Mutant
BKE22130 (Δ[gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATATTTCCCCCTTGGT, downstream forward: _UP4_ATTCCAATGGATGGGCTGAABKK22130 (Δ[gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATATTTCCCCCTTGGT, downstream forward: _UP4_ATTCCAATGGATGGGCTGAAReferences