ptpZ [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

phosphotyrosine protein phosphatase, antagonist to PtkA

locus: BSU36240

pI: 6.00

mw: 28.00 kDa

function: protein tyrosine dephosphorylation

product: phosphotyrosine protein phosphatase,
antagonist to PtkA

essential: no

ec: 3.1.3.48

synonyms: ywqE

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation]

[SW|Categories] containing this gene/protein

• [SW|biofilm formation], [SW|protein modification]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|DegU regulon], [SW|Spo0A regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,731,005 -> 3,731,769

The protein

Catalyzed reaction/ biological activity

• Protein tyrosine phosphate H₂O = protein tyrosine phosphate (according to Swiss-Prot), dephosphorylation of [protein|search|Ugd], [protein|search|TuaD] and [protein|search|PtkA] [Pubmed|15866923]

Protein family

• cpsB/capC family (according to Swiss-Prot)

Structure

• [PDB|3QY7] [Pubmed|21605684]

[SW|Interactions]

• [SW|DnaK]-[SW|PtpZ] (for dephosphorylation of [SW|DnaK]) [Pubmed|27148221]

Expression and Regulation

Operon

• ''[protein|search|tkmA]-[protein|search|ptkA]-[protein|search|ptpZ]-[protein|search|ugd]'' [Pubmed|20815827,12970183]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|20815827]

Regulatory mechanism

• [SW|Spo0A]: transcription activation [Pubmed|26283769]
• [protein|search|DegU]-P: transcription activation [Pubmed|26283769]
• [protein|search|AbrB]: transcription repression [Pubmed|20817675]

Biological materials

Mutant

• GP1609 (spc), available in [SW| Jörg Stülke]'s lab
• GP1610 (''[protein|search|ptkA]-[protein|search|ptpZ]'', spc), available in [SW| Jörg Stülke]'s lab

References

• 15866923,12970183,21605684,20815827,21605684,20817675,26283769,27148221