yhfS [2017-05-17 11:12:48]

similar to acetyl-CoA C-acetyltransferase

locus: BSU10350

pI: 5.12

mw: 38.24 kDa

protein length: 364 aa

gene length: 1092 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

Gene

Coordinates: 1,109,388 → 1,110,482

The protein

Protein family

• thiolase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|07498A0A3CB598A6E388540124A4F56E781C86FA|FadA], [protein|226100C0AC13BB345DB0F0F309DEB7F91F3770B0|MmgA]

Structure

• [PDB|3SS6] (the protein of ''B. anthracis'', 38% identity, 66% similarity)

Expression and Regulation

Operons

• genes: [gene|22215066A7BEA4E53189DE6639C19D1AD86DA7F4|yhfU]-[gene|5050649605DD782AF10FC0AEEA5F14036EC0197D|yhfT]-[gene|CF6B79564DBED3C6CAF64D01BD01D2A03675F16F|yhfS]-[gene|73CB11C654E7A92D6F59B00E0710D3AA1FD2F099|yhfR]
  description: [Pubmed|22383849]

  regulatory mechanism

  • [protein|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA]: repression, [Pubmed|11717296], in [regulon|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA regulon]

  regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|11717296]

  additional information

  • weakly expressed [http://www.ncbi.nlm.nih.gov/sites/entrez/10869096 PubMed]

• genes: [gene|5050649605DD782AF10FC0AEEA5F14036EC0197D|yhfT]-[gene|CF6B79564DBED3C6CAF64D01BD01D2A03675F16F|yhfS]-[gene|73CB11C654E7A92D6F59B00E0710D3AA1FD2F099|yhfR]
  description: [Pubmed|22383849]

  additional information

  • weakly expressed [http://www.ncbi.nlm.nih.gov/sites/entrez/10869096 PubMed]

Biological materials

Mutant

• MGNA-B279 (yhfS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1278 NBRP B. subtilis, Japan]

References

• 22383849,12368242