thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins
function
oxidative folding of proteins
product
thiol-disulfide oxidoreductase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.2|Chaperones/ protein folding][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|chaperones/ protein folding], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|ComK regulon], [SW|SigE regulon]Gene
Coordinates on the chromosome (coding sequence)
3,438,065 -> 3,438,733
Phenotypes of a mutant
loss of transformability [Pubmed|11744713]sensitive to osmotic shock [Pubmed|22540663]several proteins are absent from the membrane proteome of a ''[protein|search|bdbC]-[protein|search|bdbD]'' mutant: [Pubmed|22540663]the membrane proteins [protein|search|BglP], [protein|search|TcyP], [protein|search|SipU], [protein|search|LytA], and [protein|search|YxaI] [Pubmed|22540663]the cytoplasmic or membrane-associated proteins [protein|search|GlkX], [protein|search|ProA], [SW|PyrAA], [SW|PyrAB], [protein|search|PyrH], [protein|search|PyrE], [protein|search|PyrF], [protein|search|DegS], [protein|search|YbxA] [Pubmed|22540663]The protein
Catalyzed reaction/ biological activity
formation of thiol disulfide bonds in [SW|ComEC] and [SW|ComGC] (together with [protein|search|BdbC]) [Pubmed|11744713]Protein family
DsbA subfamily (according to Swiss-Prot)[SW|Cofactors]
Ca (2+) [Pubmed|19535335]Structure
[PDB|3EU3] (reduced form), [PDB|3EU4] (oxidized form) [Pubmed|19535335][SW|Localization]
membrane, faced to the outer side of the membrane [Pubmed|19535335]Expression and Regulation
Operon
''[protein|search|bdbD]-[protein|search|bdbC]'' [Pubmed|11744713][SW|Sigma factor]
[protein|search|SigE] [Pubmed|12480901]Regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|12480901]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|11744713]References
Reviews
Original publications
19535335,11744713,15661011,11872755,16751195,11844773,12480901,22540663 
