fsrA [2020-06-17 16:19:00]

regulatory RNA

locus: BSU_misc_RNA_69

essential: no

synonyms

Genomic Context

categories

• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]

Gene

Phenotypes of a mutant

• transcription profile of a [gene|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA] mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] [pubmed|22389480]

RNA

basic information/Evolution

• Catalyzed reaction/ biological activity: hybridizes to [gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC], [gene|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|citB], [gene|57B9E37F6232189CD47C1B41FDCF43FCB8016AEB|lutB], [gene|44DF1B7E476AD58B3CCC39300FFE0132D0D32AD0|gltA]-[gene|AA07CC52B2DD48ACC9D3375E9D531CB1ACBE485A|gltB], and [gene|AC459429A9C50463FD947C1CF9EA919B6FE3B335|leuC]-[gene|0EB4C6EE398B14B9284FFAEDBC26C866CE2070D7|leuD] mRNAs and inhibits their translation [pubmed|18697947,22389480]

Expression and Regulation

Operons

• genes: [gene|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA]
  description: [pubmed|22383849]

  regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|18697947], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

  regulation

  • induced by iron starvation (third wave, under extreme starvation, iron sparing response) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,18697947]

Biological materials

Mutant

• HB7361 Δ[gene|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA]::''cat'' (available in [SW|John Helmann]'s and [SW|Jörg Stülke]'s labs) [pubmed|18697947]
• HB7385 Δ[gene|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA]::''spc'' (available in [SW|John Helmann]'s and [SW|Jörg Stülke]'s labs) [pubmed|18697947]

labs

• [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 22427629,18697947,22389480,29133393