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sipS [Fri Jan 29 2016 18:21:07 GMT+0100 (CET)]
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sipS [Fri Jan 29 2016 18:21:07 GMT+0100 (CET)]

signal peptidase I
locus
BSU23310
pI
9.00
mw
20.00 kDa
function
protein secretion
product
signal peptidase I
essential
no
ec
3.4.21.89
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|protein secretion], [SW|membrane proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,432,316 -> 2,432,870

    Phenotypes of a mutant

  • a ''[protein|search|sipS] [protein|search|sipT]'' double mutant is not viable [Pubmed|9694797]

    • The protein

    Catalyzed reaction/ biological activity

  • cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
  • intra-membrane cleavage and thus inactivation of [protein|search|RsiV] between A66 and M67 [Pubmed|25275625]

    • Protein family

  • peptidase S26 family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|SipT], [protein|search|SipU], [protein|search|SipV]

    • Structure

  • [PDB|4NV4] (from ''Bacillus anthracis'', 40% identity)

    • [SW|Localization]

  • membrane

    • Expression and Regulation

    Operon

  • ''sipS'' [Pubmed|8951809]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8951809]

    • Labs working on this gene/protein

  • [SW|Jan Maarten van Dijl], Groningen, Netherlands

    • References

    Reviews

  • 22688815

    • Original publications

  • 9325333,9694797,8951809,10336490,25275625