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sipS [2018-09-26 10:29:05]
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sipS [2018-09-26 10:29:05]

signal peptidase I
locus
BSU23310
pI
9.72
mw
20.90 kDa
protein length
184 aa Sequence Blast
gene length
552 bp Sequence Blast
function
protein secretion
product
signal peptidase I
essential
no
ec
3.4.21.89
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,432,316 → 2,432,870

    Phenotypes of a mutant

  • a ''[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS] [gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]'' double mutant is not viable [Pubmed|9694797]

    • The protein

    Catalyzed reaction/ biological activity

  • cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
  • intra-membrane cleavage and thus inactivation of [protein|ED1DDA187692683D9862EC0E858B80CD56C48045|RsiV] between A66 and M67 [Pubmed|25275625]

    • Protein family

  • peptidase S26 family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|SipU], [protein|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|SipV], [protein|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|SipT]

    • Structure

  • [PDB|4NV4] (from ''Bacillus anthracis'', 40% identity)

    • [SW|Localization]

  • membrane

    • Expression and Regulation

    Operons

    genes
    [gene|9756DD153F0FAACB5A64B363D580AA8A9AE7FD58|ypzJ]-[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]
    description
    [Pubmed|22383849]
    view in new tab

    genes
    [gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]
    description
    [Pubmed|8951809]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8951809], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
    • view in new tab

    Biological materials

    Mutant

  • BKE23310 (Δ[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTGATTTCCTCCAATAA, downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA
  • BKK23310 (Δ[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACTGATTTCCTCCAATAA, downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA

    • Labs working on this gene/protein

  • [SW|Jan Maarten van Dijl], Groningen, Netherlands

    • References

    Reviews

  • 22688815

    • Original publications

  • 9325333,9694797,8951809,10336490,25275625,28088521,29358498