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qoxC [2017-04-24 15:34:12]
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qoxC [2017-04-24 15:34:12]

cytochrome aa3 quinol oxidase (subunit III)
locus
BSU38150
pI
6.24
mw
22.53 kDa
protein length
204 aa Sequence Blast
gene length
612 bp Sequence Blast
function
respiration
product
cytochrome aa3 quinol oxidase (subunit III)
essential
no
ec
1.10.3.-
synonyms
ipa-39d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]

    • Gene

    Coordinates
    3,914,691 → 3,915,305

    The protein

    Catalyzed reaction/ biological activity

  • Ubiquinol-8 + O2 = Ubiquinone-8 + H2O (according to Swiss-Prot)

    • Protein family

  • cytochrome c oxidase subunit 3 family (according to Swiss-Prot)

    • Structure

  • [PDB|1FFT] ([protein|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|QoxA]-[protein|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|QoxB]-[protein|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|QoxC] complex from ''E. coli'', 52% identity) [Pubmed|11017202]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|qoxA]-[gene|CBF2DCFFD8195304F942ECBA8596444F0AC47CC6|qoxB]-[gene|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC]-[gene|03335DC50CED7B38E2380640AE108ADA09A2CBDF|qoxD]
    description
    [Pubmed|1316894]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: mRNA binding, in [regulon|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB regulon]

    • regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

    • additional information

  • the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]
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    References

  • 11073895,1316894,20351111,10551842,11017202