function
utilization of urea as alternative nitrogen source
product
urease (alpha subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.2|Utilization of urea][SW|Categories] containing this gene/protein
[SW|utilization of nitrogen sources other than amino acids]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|GlnR regulon], [SW|PucR regulon], [SW|SigH regulon], [SW|TnrA regulon]The protein
Catalyzed reaction/ biological activity
Urea + H2O = CO2 + 2 NH3 (according to Swiss-Prot)Protein family
urease family (according to Swiss-Prot)[SW|Cofactors]
nickel[SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|UreA]-[protein|search|UreB]-[protein|search|UreC]Expression and Regulation
Operon
''[protein|search|ureA]-[protein|search|ureB]-[protein|search|ureC]'' [Pubmed|9287005][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9287005], [protein|search|SigH] [Pubmed|9287005]Regulation
induced by nitrogen limitation ([protein|search|GlnR], [protein|search|TnrA]) [Pubmed|9287005]induced in the presence of purine nucleotides (inducer: allantoin) ([protein|search|PucR]) [Pubmed|12374841]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|9287005,12618455]Regulatory mechanism
[protein|search|GlnR]: transcription repression [Pubmed|9287005][protein|search|TnrA]: transcription activation [Pubmed|9287005][protein|search|PucR]: transcription activation [Pubmed|12374841][protein|search|CodY]: transcription repression [Pubmed|9287005,12618455]References
Reviews
Original publications
12618455,16199586,9287005,9287005,12374841,9287005,25755103 
