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nrdF [Wed Dec 07 2016 11:32:06 GMT+0100 (CET)]
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nrdF [Wed Dec 07 2016 11:32:06 GMT+0100 (CET)]

ribonucleoside-diphosphate reductase (major subunit)
locus
BSU17390
pI
4.00
mw
38.00 kDa
function
synthesis of deoxyribonucleoside triphosphates
product
ribonucleoside-diphosphate reductase (major subunit)
essential
yes
ec
1.17.4.1
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.5|Biosynthesis/ acquisition of nucleotides/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|NrdR regulon], [SW|ResD regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,871,089 -> 1,872,078

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 2'-deoxyribonucleoside diphosphate thioredoxin disulfide H2O = ribonucleoside diphosphate thioredoxin (according to Swiss-Prot)

    • Protein family

  • ribonucleoside diphosphate reductase small chain family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YosP]

    • [SW|Cofactors]

  • Mn(2 ) [Pubmed|21561096]
  • dimanganic-tyrosyl radical (MnIII2-Y•) cofactor [Pubmed|24401092]

    • Structure

  • [PDB|4DR0] [Pubmed|22443445]

    • [SW|Interactions]

  • [protein|search|NrdE]-[protein|search|NrdF] [Pubmed|16885274]
  • [protein|search|NrdI]-[protein|search|NrdF] [Pubmed|23402532]

    • Expression and Regulation

    Operon

  • ''[protein|search|nrdI]-[protein|search|nrdE]-[protein|search|nrdF]-[protein|search|ymaB]'' [Pubmed|16885274]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16885274]

    • Regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|16885274]

    • Regulatory mechanism

  • [protein|search|ResD]: transcription activation [Pubmed|16885274]
  • [SW|NrdR]: transcription repression (predicted) [Pubmed|15949864]

    • Labs working on this gene/protein

  • [SW|Elisabeth Härtig], Braunschweig, Germany [http://www.tu-braunschweig.de/ifm/abt/jahn/groups/bs Homepage]

    • References

    Reviews

  • 17229208

    • Original Publications

  • 16885274,8969495,24401092,23402532,22443445,21561096,15949864