spoIISA [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

lethal when synthesized during vegetative growth in the absence of SpoIISB

locus: BSU12830

pI: 4.00

mw: 28.00 kDa

function: programmed cell death

product: toxin

essential: no

synonyms: ykaC

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.2|Type 2 TA systems]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|sporulation proteins], [SW|toxins, antitoxins and immunity against toxins], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigK regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,348,612 -> 1,349,358

The protein

[SW|Domains]

• three putative membrane-spanning segments and a cytoplasmic domain

Structure

• [PDB|3O6Q] (cytoplasmic fragment of [SW|SpoIISA] (CSpoIISA) in complex with [SW|SpoIISB]) [Pubmed|21147767]

[SW|Localization]

• cell membrane [Pubmed|20863891]

[SW|Interactions]

• [SW|SpoIISA]-[SW|SpoIISB] [Pubmed|21147767]

Expression and Regulation

Operon

• ''[SW|spoIISA]-[SW|spoIISB]'' [Pubmed|11371520]

Biological materials

Mutant

• 1S123 ( ''spoIISA''::''kan''), [Pubmed|11371520], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S123&Search=1S123 BGSC]

References

• 18096016,11371520,21147767,25039482,20863891,26300872,27294956