SubtiBank SubtiBank
spoIISA
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spoIISA

lethal when synthesized during vegetative growth in the absence of SpoIISB
Locus
BSU_12830
Isoelectric point
4.68
Molecular weight
28.91 kDa
Protein length
248 aa Sequence Blast
Gene length
747 bp Sequence Blast
Function
programmed cell death
Product
toxin
Essential
no
Synonyms
ykaC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
  • Lifestyles → Coping with stress → Toxins, antitoxins and immunity against toxins
  • Lifestyles → Coping with stress → Toxins, antitoxins and immunity against toxins → Type 2 TA systems
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    1,348,612 → 1,349,358

    The protein

    Protein family

  • SpoIISA toxin family (single member, according to UniProt)

    • Domains

  • three putative membrane-spanning segments and a cytoplasmic domain

    • Structure

  • 3O6Q (cytoplasmic fragment of SpoIISA (CSpoIISA) in complex with SpoIISB) PubMed

    • Localization

  • cell membrane PubMed

    • Expression and Regulation

    Operons

    Genes
    spoIISA-spoIISB
    Description
    PubMed

    Sigma factors

  • SigK: sigma factor, in SigK regulon
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    Biological materials

    Mutant

  • MGNA-A006 (spoIISA::erm), available at the NBRP B. subtilis, Japan
  • 1S123 ( spoIISA::kan), PubMed, available at BGSC
  • BKE12830 (ΔspoIISA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTCGAATCCCTCACAT, downstream forward: _UP4_ATTGAGGAGGAAGGTGAAGG
  • BKK12830 (ΔspoIISA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTCGAATCCCTCACAT, downstream forward: _UP4_ATTGAGGAGGAAGGTGAAGG

    • References

    Reviews

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    Original publications

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