gidB [Tue Dec 13 2016 11:16:38 GMT+0100 (CET)]

7-methylguanosine methyltransferase specific for the 16S rRNA, glucose-inhibited division protein

locus: BSU41000

pI: 6.00

mw: 26.00 kDa

function: rRNA modification

product: 7-methylguanosine methyltransferase specific for the 16S rRNA

essential: no

synonyms: rsmG

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.2|rRNA modification and maturation]

[SW|Categories] containing this gene/protein

• [SW|translation]

This gene is a member of the following [SW|regulons]

• [SW|ComK regulon], [SW|DnaA regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,208,870 -> 4,209,589

Phenotypes of a mutant

• low-level resistance to streptomycin, increased level of streptomycin-resistant rpsL mutants (200 times higher than in the wild type) [Pubmed|17573471]

The protein

Catalyzed reaction/ biological activity

• methylates the N7 position of nucleotide G535 in 16S rRNA [Pubmed|17573471]

Protein family

• RNA methyltransferase rsmG family (according to Swiss-Prot)

Structure

• [PDB|1XDZ]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|thdF]-[protein|search|gidA]-[protein|search|rsmG]-[protein|search|noc]'' [Pubmed|11807071]

Regulatory mechanism

• [protein|search|ComK]: transcription activation [Pubmed|11948146]
• [protein|search|DnaA]: transcription repression [Pubmed|26020636]

References

• 17573471,11948146,11807071,26020636