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bofA [Tue Dec 13 2016 11:16:29 GMT+0100 (CET)]
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bofA [Tue Dec 13 2016 11:16:29 GMT+0100 (CET)]

inhibition of the pro-sigma-K processing machinery
locus
BSU00230
pI
9.32
mw
8.00 kDa
function
control of SigK activation
product
inhibitor of pro-SigK processing
essential
no
synonyms
Outlinks
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Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|sigma factors and their control], [SW|sporulation proteins], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon], [SW|SpoIIID regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    29,772 -> 30,035

    The protein

    [SW|Localization]

  • forespore outer membrane (according to Swiss-Prot)
  • integral membrane protein [Pubmed|11959848]

    • [SW|Interactions]

  • [protein|search|BofA]-[SW|SpoIVB] [Pubmed|15292188]
  • [SW|SpoIVFB]-[protein|search|BofA], to inhibit proteolytic activity of [SW|SpoIVFB] [Pubmed|15087499]
  • [SW|SpoIVFA]-[protein|search|BofA], recruitment of [protein|search|BofA] to [SW|SpoIVFB] [Pubmed|11959848]

    • Expression and Regulation

    Operon

  • ''bofA'' [Pubmed|1315731]

    • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|1315731]

    • Regulation

  • expressed during sporulation [Pubmed|1315731]

    • Regulatory mechanism

  • repressed by [SW|SpoIIID] [Pubmed|1315731]

    • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

    • Biological materials

    Mutant

  • 1S100 ( ''bofA''::''cat''), [Pubmed|1577688], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S100&Search=1S100 BGSC]
  • 1S96 ( ''bofA''::''erm''), [Pubmed|1315731], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S96&Search=1S96 BGSC]

    • Labs working on this gene/protein

  • Simon Cutting, London, UK [http://personal.rhul.ac.uk/uhba/009/bacillus/simon_cutting.html homepage]

    • References

  • 11959848,9501233,1577688,15292188,2115401,12940997,12884008,15292188,1315731,15752199,16818230,15087499