intramembrane protease, cleaves FtsL, RsiV and RsiW as well as signal peptides after release of the secreted proteins
function
control of cell division, and SigV and SigW activity
product
intramembrane protease
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell division], [SW|proteolysis], [SW|sigma factors and their control], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
1,724,029 -> 1,725,297
Phenotypes of a mutant
defects in competence development, [SW|protein secretion] and membrane protein production [Pubmed|23155385]mutants grow slower in liquid, are not competent, can’t activate [protein|search|SigW], have [SW|cell division] defects, and decreased long term survival [Pubmed|23687273]inactivation of ''[SW|rasP]'' reduces sporulation efficiency to 1.4% that of wild type cells; delayed entry into sporulation; thin, oblong forespores [Pubmed|26735940]The protein
Catalyzed reaction/ biological activity
cleaves [protein|search|FtsL], [protein|search|RsiV] and [protein|search|RsiW]cleaves signal peptides after release of the secreted proteins [Pubmed|21810987]Protein family
peptidase M50B family (according to Swiss-Prot)[SW|Localization]
cell membrane [Pubmed|18763711][SW|Interactions]
[protein|search|RasP]-[protein|search|FtsL][protein|search|RasP]-[protein|search|RsiW][protein|search|RasP]-[protein|search|RsiV] [Pubmed|23687273]Labs working on this gene/protein
[SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas Wiegert-Dateien/Thomas Wiegert.html Homepage]References
Reviews
20836086,23479438,22381678,22688815,19189971 Original publications
16899079,15130127,18599827,17020588,19889088,18763711,20644139,21810987,23687273,23155385,26735940 
