rasP [Tue May 03 2016 10:04:19 GMT+0200 (CEST)]

intramembrane protease, cleaves FtsL, RsiV and RsiW as well as signal peptides after release of the secreted proteins

Locus: BSU16560

Isoelectric point: 5.00

Molecular weight: 46.00 kDa

Function: control of cell division, and SigV and SigW activity

Product: intramembrane protease

Essential: no

Synonyms: yluC

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell division → Other genes
• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Information processing → Protein synthesis, modification and degradation → Proteolysis → Additional proteins involved in proteolysis
• Information processing → Regulation of gene expression → Sigma factors and their control → Control of sigma factors
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• cell division, proteolysis, sigma factors and their control, membrane proteins

Gene

Coordinates on the chromosome (coding sequence): 1,724,029 -> 1,725,297

Phenotypes of a mutant

• defects in competence development, protein secretion and membrane protein production PubMed
• mutants grow slower in liquid, are not competent, can’t activate SigW, have cell division defects, and decreased long term survival PubMed
• inactivation of rasP reduces sporulation efficiency to 1.4% that of wild type cells; delayed entry into sporulation; thin, oblong forespores PubMed

The protein

Catalyzed reaction/ biological activity

• cleaves FtsL, RsiV and RsiW
• cleaves signal peptides after release of the secreted proteins PubMed

Protein family

• peptidase M50B family (according to Swiss-Prot)

Localization

• cell membrane PubMed

Interactions

• RasP-FtsL
• RasP-RsiW
• RasP-RsiV PubMed

Labs working on this gene/protein

• Thomas Wiegert, University of Bayreuth, Germany Wiegert-Dateien/Thomas Wiegert.html Homepage

References

Reviews

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Original publications

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