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alr [Fri Apr 01 2016 18:17:52 GMT+0200 (CEST)]
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alr [Fri Apr 01 2016 18:17:52 GMT+0200 (CEST)]

Locus
BSU04640
Isoelectric point
8.00
Molecular weight
43.00 kDa
Function
peptidoglycan biosynthesis
Product
alanine racemase
Essential
yes
E.C.
5.1.1.1
Synonyms
dal, alrA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/acquisition of L- and D-alanine
  • Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
  • Groups of genes → Essential genes

    • Categories containing this gene/protein

  • cell wall synthesis, biosynthesis of cell wall components, essential genes

    • Gene

    Coordinates on the chromosome (coding sequence)
    517,372 -> 518,541

    Phenotypes of a mutant

  • reported to be essential PubMed, however deletion mutants have been reported by Ferrari et al. (1985) and Xia et al (2007) PubMed
  • auxotrophy for D-alanine

    • The protein

    Catalyzed reaction/ biological activity

  • L-alanine = D-alanine (according to Swiss-Prot)

    • Protein family

  • alanine racemase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • YncD

    • Structure

  • 1L6G (with N-[5�-phosphopyridoxyl]-D-alanine, Geobacillus stearothermophilus), 1SFT (Geobacillus stearothermophilus)

    • Biological materials

    Mutant

  • alr-1, two-base mutation 526AG>T (=R176X), creating a frameshift and an immediate stop codon, available in BGSC 1A4, a D-alanine auxotroph

    • References

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