trigger enzyme: fructose-specific phosphotransferase system, EIIB component of the PTS
function
fructose uptake and phosphorylation, control of LevR activity
product
trigger enzyme: fructose-specific phosphotransferase system, EIIB component
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.27|Utilization of other polymeric carbohydrates][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.7|Utilization of fructose][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.4|Control of PRD-type regulators][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.3|Trigger enzyme] → [category|SW 3.4.3.1|Trigger enzymes of the PTS that control the activity of PRD-containing transcription factors][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|trigger enzyme], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|LevR regulon], [SW|SigL regulon]The protein
Catalyzed reaction/ biological activity
Protein EIIB N(pi)-phospho-L-histidine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)Protein family
[SW|PTS] permease, mannose permease (Man) family [Pubmed|10627040]Structure
[PDB|1BLE][SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|LevD]-[protein|search|LevE], [protein|search|LevE]-[protein|search|LevR]Expression and Regulation
Operon
''[protein|search|levD]-[protein|search|levE]-[protein|search|levF]-[protein|search|levG]-[protein|search|sacC]'' [Pubmed|2117666][SW|Sigma factor]
[protein|search|SigL] [Pubmed|1924373]Regulation
subject to carbon catabolite repression ([protein|search|CcpA], [protein|search|LevR]) [Pubmed|7592486]induced in the presence of fructose ([protein|search|LevR]) [Pubmed|1900939]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|7592486][protein|search|LevR]: transcription activation [Pubmed|1900939]References
10627040,2117666,9551099,9030753,9033408,1924373,7592486,1900939 
