threonyl-tRNA synthetase (minor)
product
threonyl-tRNA synthetase (minor)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][SW|Categories] containing this gene/protein
[SW|translation]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
3,854,256 -> 3,856,172
The protein
Catalyzed reaction/ biological activity
ATP L-threonine tRNA(Thr) = AMP diphosphate L-threonyl-tRNA(Thr) (according to Swiss-Prot) Protein family
class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|ThrS], one of the two proteins has to be present for viability [Pubmed|17114254]Structure
[PDB|1TJE] (from ''Escherichia coli'', 43% identity, 65% similarity) [Pubmed|15525511][SW|Localization]
cytoplasm (according to Swiss-Prot)Additional information
:subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] Expression and Regulation
Operon
''[protein|search|thrZ]-[protein|search|ywhA]'' [Pubmed|1379177][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1379177]Regulation
induced by threonine limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] [PubMed|21815947] References
19258532,8288542,1379177,17114254,21815947 
