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dnaD [2019-01-03 14:03:06]
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dnaD [2019-01-03 14:03:06]

initiation of chromosome replication, part of the replisome
Locus
BSU22350
Isoelectric point
7.17
Molecular weight
27.49 kDa
Protein length
232 aa Sequence Blast
Gene length
696 bp Sequence Blast
Function
DNA replication
Product
initiation of chromosome replication
Essential
yes
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA replication
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    2,345,433 → 2,346,131

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • DnaD-mediated untwisting of the DNA stimulates Nth endonuclease activity at AP sites PubMed
  • required for the assembly of the replicative helicase DnaC at the origin of replication PubMed
  • interaction with DnaA inhibits the ability of DnaA to bind cooperatively to DNA PubMed

    • Protein family

  • DNA polymerase type-Y family (according to Swiss-Prot)

    • Structure

  • 2C79 (N-terminal domain)

    • Localization

  • Membrane-proximal (Spotty) PubMed

    • Expression and Regulation

    Operons

    Genes
    asnS-dnaD-nth-ypoC
    Description
    PubMed
    view in new tab

    Genes
    dnaD-nth
    Description
    PubMed

    Regulation

  • constitutively expressed PubMed
    • view in new tab

    Labs working on this gene/protein

  • Alan Grossman, MIT, Cambridge, MA, USA

    • References

    Reviews

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    Original publications

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