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spoIIAB [Mon Aug 31 2015 13:55:24 GMT+0200 (CEST)]
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spoIIAB [Mon Aug 31 2015 13:55:24 GMT+0200 (CEST)]

anti-protein serine kinase
locus
BSU23460
pI
4.38
mw
16.00 kDa
function
control of SigF activity
septation; phosphorylation and inactivation of SpoIIAA
product
anti-protein serine kinase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]

    • [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|sigma factors and their control], [SW|sporulation proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|SigF regulon], [SW|SigG regulon], [SW|SigH regulon], [SW|SinR regulon], [SW|Spo0A regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + a protein = ADP + a phosphoprotein (according to Swiss-Prot)

    • Protein family

  • anti-[protein|search|sigma-factor] family (according to Swiss-Prot)

    • Structure

  • [PDB|1L0O] (complex with SigF, Geobacillus stearothermophilus), [PDB|1TIL] (complex with SpoIIAA, Geobacillus stearothermophilus)

    • [SW|Interactions]

  • [SW|SpoIIE]-[SW|SpoIIAB], [protein|search|RsbV]-[SW|SpoIIAB] [Pubmed|8764398]
  • [SW|SpoIIAB]-[protein|search|SigG] [Pubmed|8885263]
  • [SW|SpoIIAB]-[protein|search|SigF], [SW|SpoIIAB]-[SW|SpoIIAA] [Pubmed|15201047]

    • Expression and Regulation

    Operon

  • ''[protein|search|dacF]-[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]
  • ''[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]

    • [SW|Sigma factor]

  • ''[protein|search|dacF]'': [protein|search|SigF], [protein|search|SigG]
  • ''[SW|spoIIAA]'': [protein|search|SigH]

    • Regulation

  • ''[protein|search|dacF]'': expressed during sporulation
  • ''[SW|spoIIAA]'': expressed early during sporulation
  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/1556084,15687200 PubMed]

    • Regulatory mechanism

  • ''[SW|spoIIAA]'': activated by [SW|Spo0A] and repressed by [protein|search|SinR]
  • [SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/1556084,15687200 PubMed]
  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]

    • Labs working on this gene/protein

  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

    • References

    Modeling of [protein|search|SigF] activation

  • 24067622,22312331,20298743

    • Original Publications

  • 8358793,7570023,15023063,15351644,8460142,9077448,12923101,8820658,10864495,16824103,12867473,8955289,10476035,8764398,8764397,14744853,9826498,9826499,15175314,1938874,12676949,8126438,11684022,8846916,1948031,3114419,11846550,15201047,2123551,15205443,8885263,8332059,8168129,11701124,8824593,1556084,15687200,20817675,25278935