fructoselysine-6-P-glycosidase
function
metabolism of aminoacylated fructose
product
fructoselysine-6-P-glycosidase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of nitrogen sources other than amino acids], [SW|membrane proteins], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|FrlR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,351,110 -> 3,352,096
The protein
Modification
phosphorylated on Arg-48 [Pubmed|22517742]Structure
[PDB|3EUA][SW|Localization]
membrane associated [Pubmed|18763711]Expression and Regulation
Operon
''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' [Pubmed|23175651,21347729]''[protein|search|frlB]-[protein|search|frlO]'' [Pubmed|23175651]''[protein|search|frlB]'' [Pubmed|23175651]Regulation
'' [protein|search|frlB]'': repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]''[protein|search|frlB]'': induced in the presence of fructosamine ([protein|search|FrlR]) [Pubmed|21398478]Regulatory mechanism
[protein|search|CodY]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed1], [http://www.ncbi.nlm.nih.gov/sites/entrez/18083814 PubMed2][protein|search|FrlR]: transcription repression [Pubmed|21398478]Additional information
the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in a ''[SW|cshA]'' mutant [PubMed|23175651]the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in the presence of [SW|NusA] [http://www.nature.com/articles/nmicrobiol20157 Reference]belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
22517742,23175651,21815947,15556630,18083814,12618455,21347729,18763711,21398478,15378759 
