immunity protein, protects the cell against the toxic activity of WapA
function
intercellular competition
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.18|Toxins, antitoxins and immunity against toxins/ based on similarity][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|toxins, antitoxins and immunity against toxins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|DegU regulon], [SW|WalR regulon], [SW|YvrHb regulon]Gene
Coordinates on the chromosome (coding sequence)
4,023,054 -> 4,023,482
Phenotypes of a mutant
severe growth defect [Pubmed|20815827]The protein
Catalyzed reaction/ biological activity
[protein|search|WapI] inhibits the toxic activity of [protein|search|WapA] [Pubmed|23572593]Modification
phosphorylation on (Tyr-102 OR Ser-105) [Pubmed|17218307][SW|Interactions]
[protein|search|WapA]-[protein|search|WapI] [Pubmed|23572593]Expression and Regulation
Operon
''[protein|search|wapA]-[protein|search|wapI]'' [Pubmed|16306698][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23199363]Regulation
repressed at high salt concentration ([protein|search|DegU]-P) [Pubmed|9537385]Regulatory mechanism
[protein|search|DegU]-P: transcription repression [Pubmed|9537385]activated by [SW|YvrHb] [Pubmed|16306698][protein|search|WalR]: transcription repression [Pubmed|23199363]Biological materials
Mutant
MGNA-B789 (yxxG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1788 NBRP B. subtilis, Japan]References
16672620,20815827,17218307,16306698,9537385,23572593,23199363,26923784 
