malA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

6-phospho-alpha-glucosidase

locus: BSU08180

pI: 4.74

mw: 50.00 kDa

function: maltose utilization

product: 6-phospho-alpha-glucosidase

essential: no

ec: 3.2.1.122

synonyms: glvG, glvA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.22|Utilization of maltose]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|GlvR regulon]

Gene

Coordinates on the chromosome (coding sequence): 890,022 -> 891,371

The protein

Catalyzed reaction/ biological activity

• Maltose 6'-phosphate + H₂O = D-glucose + D-glucose 6-phosphate (according to Swiss-Prot)

Protein family

• glycosyl hydrolase 4 family (according to Swiss-Prot)

Structure

• [PDB|1U8X]

[SW|Localization]

• membrane associated [Pubmed|18763711]

Expression and Regulation

Operon

• ''[protein|search|malA]-[protein|search|glvR]-[protein|search|malP]'' [Pubmed|11489864]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|11489864]

Regulation

• induction by maltose ([protein|search|GlvR]) [Pubmed|11489864]
• repressed by glucose ([protein|search|CcpA]) [Pubmed|11489864]

Regulatory mechanism

• [protein|search|GlvR]: transcription activation [Pubmed|11489864]
• [protein|search|CcpA]: transcription repression [Pubmed|11489864]

References

• 22900538,16707683,10627040,18763711,9765262,11489864,17676871,15341727,20618987