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mstX [Wed Jan 06 2016 13:54:08 GMT+0100 (CET)]
membrane-integrating protein for membrane protein expression, MISTIC
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|biofilm formation], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SinR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,218,525 -> 3,218,857
Phenotypes of a mutant
reduced [SW|biofilm formation] (can be suppressed by inactivation of ''[protein|search|sinR]'') [Pubmed|23737939]overexpression result in increased [SW|biofilm formation] even in a domesticated strain background [Pubmed|23737939]The protein
Structure
[PDB|1YGM] [Pubmed|15731457][SW|Localization]
integral membrane protein that folds autonomously into the membrane, bypassing the cellular translocon machinery [Pubmed|15731457]Expression and Regulation
Operon
''[protein|search|mstX]-[protein|search|yugO]'' [Pubmed|23737939]Regulation
repressed by [protein|search|SinR] [Pubmed|23737939]Regulatory mechanism
[protein|search|SinR]: transcription repression [Pubmed|23737939]References
16704729,19475664,21097953,15731457,23737939,25177765 
