ribosome-nascent chain sensor of membrane protein biogenesis
function
control of yidC2 translation
product
sensor of SpoIIIJ activity
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.12|Translation/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|membrane proteins]The protein
Catalyzed reaction/ biological activity
acts as a kind of "leader peptide" that does or does not allow translation through a hairpin structure in the ''[SW|yidC2]'' mRNA [Pubmed|19779460][SW|Domains]
N-terminal transmembrane domain [Pubmed|22864117]the C-terminal domain interacts with the ribosome and arrests the own translation elongation [Pubmed|22864117]Structure
[http://www.ebi.ac.uk/pdbe/entry/emdb/EMD-6306 EMD-6306] ([protein|search|MifM]-stalled [SW|ribosome] complex) [Pubmed|25903689][PDB|3J9W] ([protein|search|MifM]-stalled [SW|ribosome] complex) [Pubmed|25903689][SW|Localization]
membrane [Pubmed|19779460][SW|Interactions]
the C-terminus of MifM interacts with the ribosomal polypeptide exit tunnel ([protein|search|RplD], [protein|search|RplV]) [Pubmed|25903689,19779460][SW|SpoIIIJ]-[protein|search|MifM] [Pubmed|22864117][protein|search|RplD]-[protein|search|MifM] [Pubmed|25903689][protein|search|RplV]-[protein|search|MifM] [Pubmed|25903689][SW|23S rRNA]-[protein|search|MifM] [Pubmed|25903689]Expression and Regulation
Operon
''[protein|search|mifM]-[SW|yidC2]'' [Pubmed|22383849]References
19779460,21383133,20525796,22456704,22383849,22864117,25313395,25903689 
