epsG [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

extracellular polysaccharide synthesis

Locus: BSU34310

Isoelectric point: 9.38

Molecular weight: 42.00 kDa

Function: biofilm formation

Product: unknown

Essential: no

Synonyms: yveQ

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Matrix polysaccharide synthesis
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• biofilm formation, membrane proteins

This gene is a member of the following regulons

• AbrB regulon, EAR riboswitch, RemA regulon, SinR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,522,170 -> 3,523,273

The protein

Localization

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO PubMed

Sigma factor

• SigA PubMed

Regulation

• repressed by SinR PubMed

Regulatory mechanism

• SinR: transcription anti-activation (prevents binding of RemA) PubMed
• RemA: transcription activation PubMed
• AbrB: transcription repression PubMed

Additional information

• induction by sequestration of SinR by SinI or SlrA PubMed
• the 'epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO' operon is not expressed in a 'ymdB' mutant PubMed
• the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] (this is likely due to the increased stability of the 'sinR' mRNA) PubMed
• the [[EAR riboswitch]] (eps-associated [[RNA switch]]) located between' epsB' and 'epsC' mediates processive antitermination and allows expression of the long eps operon PubMed

Labs working on this gene/protein

• Richard Losick, Harvard Univ., Cambridge, USA homepage

References

Reviews

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=The EAR RNA switch=

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