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rnz [Mon Jan 18 2016 17:47:48 GMT+0100 (CET)]
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rnz [Mon Jan 18 2016 17:47:48 GMT+0100 (CET)]

RNase Z
locus
BSU23840
pI
5.00
mw
33.00 kDa
function
processing of CCA-less tRNA precursors
product
endoribonuclease Z
essential
yes
synonyms
yqjK

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|RNAses], [SW|translation], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,478,006 -> 2,478,929

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs (according to Swiss-Prot)
  • 3' end maturation of tmRNA [Pubmed|25402410]
  • Protein family

  • [SW|RNase] Z family (according to Swiss-Prot)
  • Structure

  • [PDB|2FK6] (in complex with tRNA-Thr) [Pubmed|22940585], [PDB|1Y44]
  • Expression and Regulation

    Operon

  • ''rnz'' (according to [http://dbtbs.hgc.jp/COG/prom/yqjK.html DBTBS])
  • Labs working on this gene/protein

  • [SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]
  • References

    Reviews

  • 19215776,17599240,25878039
  • Original Publications

  • 17005971,12941704,15654328,16518398,22940585,25402410,24022488