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bioW [Fri Oct 02 2015 17:01:31 GMT+0200 (CEST)]
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bioW [Fri Oct 02 2015 17:01:31 GMT+0200 (CEST)]

pimeloyl-CoA synthase (6-carboxyhexanoate-CoA ligase)
locus
BSU30240
pI
5.00
mw
29.00 kDa
function
biosynthesis of biotin
product
pimeloyl-CoA synthase
essential
no
ec
6.2.1.14
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • This gene is a member of the following [SW|regulons]

  • [SW|BirA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,094,679 -> 3,095,455

    The protein

    Catalyzed reaction/ biological activity

  • ATP 6-carboxyhexanoate CoA = AMP diphosphate 6-carboxyhexanoyl-CoA (according to Swiss-Prot)

    • Protein family

  • bioW family (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]

    • Regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]

    • Regulatory mechanism

  • [protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]

    • References

    Reviews

  • 21437340

    • Original publications

  • 8763940,8892842,11717296,12368242