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frlD [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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frlD [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

fructosamine kinase
locus
BSU32570
pI
4.00
mw
30.00 kDa
function
metabolism of sugar amines
product
fructosamine kinase
essential
no
synonyms
yurL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources], [SW|utilization of nitrogen sources other than amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|FrlR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,347,051 -> 3,347,905

    The protein

    Protein family

  • carbohydrate kinase pfkB family (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' [Pubmed|23175651,21347729]

    • Regulation

  • '' [protein|search|frlB]'': repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]
  • ''[protein|search|frlB]'': induced in the presence of fructosamine ([protein|search|FrlR]) [Pubmed|21398478]

    • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed1], [http://www.ncbi.nlm.nih.gov/sites/entrez/18083814 PubMed2]
  • [protein|search|FrlR]: transcription repression [Pubmed|21398478]

    • Additional information

  • the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]
  • the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in a ''[SW|cshA]'' mutant [PubMed|23175651]
  • the ''[protein|search|frlB]-[protein|search|frlO]-[protein|search|frlN]-[protein|search|frlM]-[protein|search|frlD]'' operon is not expressed in the presence of [SW|NusA] [http://www.nature.com/articles/nmicrobiol20157 Reference]

    • References

  • 23175651,21815947,15556630,16153181,21347729,12618455,21398478