apurinic/apyrimidinic endonuclease , endonuclease III, removes abasic sites during base excision repair
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.2|A/P endonucleases][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]Gene
Phenotypes of a mutant
the mutant is sensititive to exposure to H2O2 [Pubmed|21954439]The protein
Catalyzed reaction/ biological activity
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate (according to Swiss-Prot)Effectors of protein activity
activity is stimulated by untwisting of the DNA (by [protein|search|DnaD], [protein|search|Hbs], or [protein|search|YonN]) [Pubmed|21954439]Structure
[PDB|1P59] (complex with DNA, Geobacillus stearothermophilus)Expression and Regulation
Operon
''[protein|search|dnaD]-[protein|search|nth]'' [Pubmed|21954439]Regulation
constitutively expressed [Pubmed|21954439]expression is transiently increased after treatment with H2O2 [Pubmed|21954439]References
Reviews
Original publications
12840008,21954439,24914186 
