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minJ [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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minJ [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

topological determinant of cell division, part of the Min system (with Z ring placement)
locus
BSU35220
pI
9.00
mw
43.00 kDa
function
cell division site selection
product
topological determinant of cell division
essential
no
synonyms
yvjD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.1|The Min system]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|membrane proteins], [SW|sporulation/ other]

    • This gene is a member of the following [SW|regulons]

  • [SW|DegU regulon], [SW|SigD regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,620,346 -> 3,621,539

    Phenotypes of a mutant

  • inactivation of ''[SW|minJ]'' reduces sporulation efficiency to 36% that of wild type cells; delayed entry into sporulation and aberrant forespores [Pubmed|26735940]

    • The protein

    Catalyzed reaction/ biological activity

  • The Min system prevents minicell formation adjacent to recently completed division sites by promoting the disassembly of the cytokinetic ring, thereby ensuring that cell division occurs only once per cell cycle [Pubmed|20352045]
  • required for oriC placement during spore development [Pubmed|27059541]

    • [SW|Localization]

  • forms rings at the division septum [Pubmed|22108385]
  • cell membrane [Pubmed|23264578]

    • [SW|Interactions]

  • ([protein|search|MinC]-[protein|search|MinD])-[protein|search|MinJ]-[SW|DivIVA] [Pubmed|20352045], [protein|search|MinJ] binds to the N-terminal lipid-binding domain of [SW|DivIVA] [Pubmed|23264578]

    • Expression and Regulation

    Operon

  • ''[SW|swrAA]-[protein|search|minJ]'' [Pubmed|16030230]

    • [SW|Sigma factor]

  • [protein|search|SigD] [Pubmed|18567663], [protein|search|SigA] [Pubmed|18567663]

    • Regulatory mechanism

  • [protein|search|DegU]-P: transcription activation ([protein|search|SigA] promoter) [Pubmed|18567663]

    • Biological materials

    two-hybrid system

  • ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab

    • Labs working on this gene/protein

  • [SW|Daniel Kearns], Indiana University, Bloomington, USA, [http://www.bio.indiana.edu/facultyresearch/faculty/Kearns.html homepage]
  • [SW|Marc Bramkamp], University of Cologne, Cologne, Germany [http://www.kraemerlab.uni-koeln.de/celldivision.php homepage]

    • References

    Reviews

  • 19884039,24367361

    • Original Publications

  • 19019154,16030230,18976281,20352045,18567663,22108385,22457634,23264578,26735940,27059541