purine nucleoside transporter
product
purine nucleoside transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter][category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|G-box]Gene
Coordinates on the chromosome (coding sequence)
4,005,752 -> 4,006,945
Phenotypes of a mutant
a ''[protein|search|nupN] [protein|search|nupG]'' double mutant is unable to utilize externally provided guanosine [Pubmed|21926227]The protein
Protein family
SLC28A transporter family (according to Swiss-Prot)[SW|Localization]
cell membrane [Pubmed|18763711]Expression and Regulation
Operon
''nupGRegulation
expression activated by glucose (4.3 fold) [Pubmed|12850135]repressed by hypoxanthine and guanine, [protein|search|PurR]-independent, [protein|search|G-box][Pubmed|12923093]Regulatory mechanism
[protein|search|G-box]: transcriptional termination/ antitermination [SW|riboswitch] [Pubmed|12923093]Biological materials
Mutant
CS219 (''[protein|search|nupG]''::''aphA3'', available in [SW|Colin Harwood]'s and [SW|Jörg Stülke]'s labs) [Pubmed|27197833]References
12850135,18763711,12923093,21926227,27197833 
