rhaEW [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

bifunctional-rhamnulose-phosphate aldolase/L-lactate dehydrogenase

locus: BSU31220

pI: 5.00

mw: 75.00 kDa

function: utilizatio of rhamnose and rhamnogalacturonan (pectin)

product: bifunctional-rhamnulose-phosphate aldolase/L-lactate dehydrogenase

essential: no

synonyms: yulA, yuwG

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.12|Utilization of rhamnose]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|RhaR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,201,860 -> 3,203,929

The protein

Catalyzed reaction/ biological activity

• rhamnulose-1-phosphate --> dihydroxyacetone-phosphate L-lactate [Pubmed|24391637]

Protein family

• short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)

[SW|Cofactors]

• NAD [Pubmed|24391637]

Expression and Regulation

Operon

• ''[SW|rhaEW]-[protein|search|rhaR]-[protein|search|rhaB]-[protein|search|rhaM]-[protein|search|rhaA]'' [Pubmed|26712933,22383849]

[SW|Sigma factor]

• [SW|SigA] [Pubmed|26712933]

Regulation

• induced by rhamnose (molecular inducer: rhamnulose-1-phosphate) ([SW|RhaR]) [Pubmed|26712933]
• repressed in the presence of glucose and other preferred carbon sources ([SW|CcpA]) [Pubmed|26712933]

Regulatory mechanism

• [SW|RhaR]: transcription repression [Pubmed|26712933]
• [SW|CcpA]: transcription repression [Pubmed|26712933]

References

• 26712933,24391637,22383849