2-keto-myo-inositol dehydratase, dehydration of 2-keto-myo-inositol (2nd reaction)
function
myo-inositol catabolism
product
2-keto-myo-inositol dehydratase,
dehydration of 2-keto-myo-inositol (2nd reaction)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|IolR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,078,173 -> 4,079,066
The protein
Catalyzed reaction/ biological activity
2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O (according to Swiss-Prot)Protein family
iolE/mocC family (according to Swiss-Prot)Structure
[PDB|3CNY] (from ''Lactobacillus plantarum wcfs1 mutant'', 63% identity, 78% similarity)Expression and Regulation
Operon
''[protein|search|iolA]-[protein|search|iolB]-[protein|search|iolC]-[protein|search|iolD]-[protein|search|iolE]-[protein|search|iolF]-[protein|search|iolG]-[protein|search|iolH]-[protein|search|iolI]-[protein|search|iolJ]'' [Pubmed|9226270][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9226270]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]induced by inositol ([protein|search|IolR]) [Pubmed|9887260,9226270]Regulatory mechanism
[protein|search|IolR]: transcription repression [Pubmed|9887260,9226270][protein|search|CcpA]: transcription repression [Pubmed|10666464]Labs working on this gene/protein
[SW|Yasutaro Fujita], University of Fukuyama, Japan[[Ken-ichi Yoshida]], Kobe University, JapanReferences
9226270,14993306,9887260,18310071,14993306 
