sipT [Mon Aug 31 2015 13:54:04 GMT+0200 (CEST)]

signal peptidase I

locus: BSU14410

pI: 9.00

mw: 21.00 kDa

function: protein secretion

product: signal peptidase I

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|protein secretion], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|DegU regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,511,308 -> 1,511,889

Phenotypes of a mutant

• a ''[protein|search|sipS] [protein|search|sipT]'' double mutant is not viable [Pubmed|9694797]

The protein

Catalyzed reaction/ biological activity

• Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

Protein family

• peptidase S26 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|SipS], [protein|search|SipU], [protein|search|SipV]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''sipT'' [Pubmed|9694797]

Regulatory mechanism

• [protein|search|DegU]: transcription activation [Pubmed|9694797]

Labs working on this gene/protein

• [SW|Jan Maarten van Dijl], Groningen, Netherlands

References

Reviews

• 22688815

Original publications

• 11807061,9325333,9694797