bceR [Fri Dec 23 2016 16:22:50 GMT+0100 (CET)]

two-component response regulator (OmpR family), regulation of bceA-bceB in response to external (bacitracin, plectasin, mersacidin and actagardine) and internal (SdpC, SkfA) antimicrobial peptides

locus: BSU30400

pI: 5.00

mw: 26.00 kDa

function: resistance against toxic peptides

product: two-component response regulator (OmpR family)

essential: no

synonyms: ytsA

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

[SW|Categories] containing this gene/protein

• [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 3,113,187 -> 3,113,882

The protein

Protein family

• [SW|OmpR family]

Modification

• phosphorylated by [protein|search|BceS] on an Asp residue

Structure

• [PDB|1KGS] (DrrD from ''Thermotoga maritima '', 32% identity) [Pubmed|11839301]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|BceS]-[protein|search|BceR] [Pubmed|25118291]

Expression and Regulation

Operon

• ''[protein|search|bceR]-[protein|search|bceS]'' [Pubmed|12399481]

Biological materials

Mutant

• MGNA-A133 (ytsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/133 NBRP B. subtilis, Japan]

References

Reviews

• 27344142

Original publications

• 10094672,18394148,12890034,14651641,21283517,20606066,17905982,25118291,22964256,21078927,26199330,26364265,11839301,27997719