two-component response regulator ([SW|OmpR family]), regulation of [gene|8E0DE8FE7E9C12495C4DCADA74D838FED088867D|bceA]-[gene|search|bceB ]in response to external (bacitracin, plectasin, mersacidin and actagardine) and internal ([protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC], [protein|DDB0022F50999AC52809D651C9CC5A5FDC71302C|SkfA]) antimicrobial peptides
function
resistance against toxic peptides
product
two-component response regulator ([SW|OmpR family])
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]Gene
Coordinates
3,113,187 → 3,113,882
The protein
Protein family
[SW|OmpR family][SW|Domains]
[SW|Response regulatory domain] (aa 3-116) (according to UniProt)Modification
phosphorylated by [protein|08F24CA21DC54031F6158AC0C772F3B520E5A849|BceS] on an Asp residueStructure
[PDB|1KGS] (DrrD from ''Thermotoga maritima '', 32% identity) [Pubmed|11839301][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]-[gene|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS]
description
[Pubmed|12399481]
view in new tabBiological materials
Mutant
MGNA-A133 (ytsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/133 NBRP B. subtilis, Japan]BKE30400 (Δ[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE30400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAABKK30400 (Δ[gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK30400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAAReferences
Reviews
27344142,28152228,29404338 Original publications
10094672,18394148,12890034,14651641,21283517,20606066,17905982,25118291,22964256,21078927,26199330,26364265,11839301,27997719