bceR [2019-08-28 12:30:16]

two-component response regulator (OmpR family), regulation of bceA-bceB in response to external (bacitracin, plectasin, mersacidin and actagardine) and internal (SdpC, SkfA) antimicrobial peptides

Locus: BSU_30400

Isoelectric point: 5.29

Molecular weight: 26.72 kDa

Protein length: 231 aa

Gene length: 696 bp

Function: resistance against toxic peptides

Product: two-component response regulator (OmpR family)

Essential: no

Synonyms: ytsA

Genomic Context

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Categories containing this gene/protein

• Information processing → Regulation of gene expression → Transcription factors and their control → Two-component system response regulators
• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
• Groups of genes → Phosphoproteins → Phosphorylation on an Asp residue

Gene

Coordinates: 3,113,187 → 3,113,882

The protein

Protein family

• OmpR family

Modification

• phosphorylated by BceS on an Asp residue

Structure

• 1KGS (DrrD from Thermotoga maritima , 32% identity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: bceR-bceS
  Description: PubMed

Biological materials

Mutant

• MGNA-A133 (ytsA::erm), available at the NBRP B. subtilis, Japan
• BKE30400 (ΔbceR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAA
• BKK30400 (ΔbceR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAATCGACTCACCGCACTTT, downstream forward: _UP4_ATCGCGAAGGAAGAGGACAA

References

Reviews

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Original publications

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