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hisF [2017-8-11 16:0:3]
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hisF [2017-8-11 16:0:3]

imidazole glycerol phosphate synthase (synthase subunit)
locus
BSU34870
pI
5.24
mw
27.14 kDa
protein length
252 aa Sequence Blast
gene length
756 bp Sequence Blast
function
biosynthesis of histidine
product
imidazole glycerol phosphate synthase (synthase subunit)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]

    • Gene

    Coordinates
    3,583,562 → 3,584,320

    The protein

    Catalyzed reaction/ biological activity

  • 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H2O (according to Swiss-Prot)

    • Protein family

  • hisA/hisF family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|148F0C7983250F50676D234DB713E532AA55DDBF|HisA]

    • Structure

  • [PDB|1KA9] (the [protein|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|HisF]-[protein|DEB3122A3EA36545759FAA6F86F71F971CA5F011|HisH] complex from ''Thermus thermophilus'', 59% identity) [Pubmed|12417026]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • Expression and Regulation

    Operons

    genes
    [gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
    description
    [Pubmed|12107147]

    regulatory mechanism

  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
  • expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
    • view in new tab

    References

    Reviews

  • 12859215

    • Original publications

  • 12107147,15378759,12417026,27766092