hisF [2017-8-11 16:0:3]

imidazole glycerol phosphate synthase (synthase subunit)

Locus: BSU34870

Isoelectric point: 5.24

Molecular weight: 27.14 kDa

Protein length: 252 aa

Gene length: 756 bp

Function: biosynthesis of histidine

Product: imidazole glycerol phosphate synthase (synthase subunit)

Essential: no

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of histidine

Gene

Coordinates: 3,583,562 → 3,584,320

The protein

Catalyzed reaction/ biological activity

• 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H₂O (according to Swiss-Prot)

Protein family

• hisA/hisF family (according to Swiss-Prot)

Paralogous protein(s)

• HisA

Structure

• 1KA9 (the HisF-HisH complex from Thermus thermophilus, 59% identity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: hisZ-hisG-hisD-hisB-hisH-hisA-hisF-hisI
  Description: PubMed

  Regulatory mechanism

  • YlxR: regulation, PubMed, in YlxR regulon

  Regulation

  • expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
  • expression depends on functional YlxR PubMed

References

Reviews

Loading

Original publications

Loading