hisF [Sun Nov 27 2016 17:41:06 GMT+0100 (CET)]

imidazole glycerol phosphate synthase (synthase subunit)

Locus: BSU34870

Isoelectric point: 5.00

Molecular weight: 27.00 kDa

Function: biosynthesis of histidine

Product: imidazole glycerol phosphate synthase (synthase subunit)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of histidine

Categories containing this gene/protein

• biosynthesis/ acquisition of amino acids, most abundant proteins

Gene

Coordinates on the chromosome (coding sequence): 3,583,562 -> 3,584,320

The protein

Catalyzed reaction/ biological activity

• 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H₂O (according to Swiss-Prot)

Protein family

• hisA/hisF family (according to Swiss-Prot)

Paralogous protein(s)

• HisA

Structure

• 1KA9 (the HisF-HisH complex from Thermus thermophilus, 59% identity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Interactions

• HisF-HisH PubMed

Expression and Regulation

Operon

• hisZ-hisG-hisD-hisB-hisH-hisA-hisF-hisI PubMed

Regulation

• repressed by casamino acids PubMed
• expression during spore germination is strongly reduced under conditions of osmotic stress PubMed

Additional information

• belongs to the 100 [[most abundant proteins]] PubMed

References

Reviews

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Original publications

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