imidazole glycerol phosphate synthase (synthase subunit)
function
biosynthesis of histidine
product
imidazole glycerol phosphate synthase (synthase subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
3,583,562 -> 3,584,320
The protein
Catalyzed reaction/ biological activity
5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H2O (according to Swiss-Prot)Protein family
hisA/hisF family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|HisA]Structure
[PDB|1KA9] (the [SW|HisF]-[SW|HisH] complex from ''Thermus thermophilus'', 59% identity) [Pubmed|12417026][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[SW|HisF]-[SW|HisH] [Pubmed|12417026]Expression and Regulation
Operon
''[protein|search|hisZ]-[protein|search|hisG]-[protein|search|hisD]-[protein|search|hisB]-[protein|search|hisH]-[protein|search|hisA]-[protein|search|hisF]-[protein|search|hisI]'' [Pubmed|12107147]Regulation
repressed by casamino acids [Pubmed|12107147]expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
Reviews
Original publications
12107147,15378759,12417026,27766092 
